Endostain ELISA Kit 内皮抑制素 (BI-20742 )
背景简介:Endostatin是一种内源性的血管生成抑制剂。Endostatin在受伤肾组织的肾小管细胞纤维化进程中高度表达。因此,Endostatin是慢性肾病检测的潜在标记物。对于微血管组织损伤病人包括:动脉硬化、脑缺血,Endostatin水平显著升高。
产品优势:
- 检测范围宽
- 6个即用型校准品
- 可当日检测,半小时内出结果
- 只需5ul样本
- 严格按照ICH要求,证实可用于人样本检测
- 可靠、重复性好的实验结果:批内<6%,批间<5%
试剂盒特点:
1)检测方法:夹心ELISA,96孔,HRP/TMB显色系统
2) 样本类型:血清、血浆(柠檬酸盐抗凝、EDTA抗凝、肝素抗凝)、尿(参照对应的protocol)
3)样品量:5ul
4)标准品范围:0-80 nmol/L(0-1600ng/ml)
5)检测灵敏度:0.02nmol/L(0+3SD)
6)孵育条件:2h/1h/30min,室温
7)单位转换:1 ng/ml = 0.05 nmol/l (MW = 20 kDa)
8)特异性:人样本与其他种属无交叉反应
参考文献:
- Elevated plasma levels of endostatin are associated with chronic kidney disease. J Chen, LL Hamm, et al.Am J Nephrol, Jan 2012; 35(4): 335-340
- Early-onset coronary artery disease after pediatric kidney transplantation: implicatingthe angiogenesi inhibitor, endostatin. CW Iqbal,et al. Am Surg, Jun 2011; 77(6): 731-735
- Immobilized kidney 28-kDa endostatin-related (KES28kDa) fragment promotes endothelial cell survival.MH Bellini, et al. Am J Nephrol, Jan 2010; 31(3): 255-261
- Endostatin and angiostatin are increased in diabetic patients with coronary artery disease and associated with impaired coronary collateral formation. Neel R. Sodha, et al.Am J Physiol Heart Circ Physiol, Feb 2009; 296: H428-H434