CVFm (Cobra Venom Factor)
报价：2000.00
| Product ID | L8117 |
| Name | CVFm (Cobra Venom Factor) |
| Molecular formula | Three polypeptide chains of 627-amino acid, 379-amino acid, 252-amino acid subunits |
| Description | It is a non-toxic, complement-activating component of cobra venom. Purified from Naja melanoleuca venom, a non-CITES Naja species. Three polypeptide chains of 627-amino acid, 379-amino acid, 252-amino acid subunits with molecular masses respectively of about 70, 50, and 30 kDa, the two large subunits being glycosylated. From Naja melanoleuca venom. |
| Biological activity | It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely resistant to the actions of complement regulatory factors H (CFH) and I (CFI). Therefore, CVF continuously activates complement resulting in the depletion of complement activity. Field of use: Itis used for immuno-suppression, decomplementing bloodin vivo&in vitro, its dosage for mice is about 1µg per gram of body weight. |
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